For example, the cause of Parkinson's disease is increased activity of the indirect path (due to the reduction of dopaminergic transmission via Dl-receptors, increased activity of the ho-linergicheskih, glutamatergic and serotonergic ways sometimes) provided a simultaneous slowdown in the direct path, which is also the cause of Artane side effects, but through a system of D-receptors. Therefore, in Parkinson's disease in order to restore the balance of neurotransmitter and neurophysiological used not only Artane 2mg, increasing the activity of the dopaminergic system, but Trihexyphenidyl, reducing the activity of the cholinergic system (anticholinergics), and glutamatergic systems (amantadine).
Hyperkinesis are usually the result of a disturbance of the balance of direct and indirect ways - they are associated with increased activity of the direct path and indirect path of reduced activity. In neurochemical terms of hyperkinesis caused by increased activity of the dopaminergic system or decreased activity of GABAergic and cholinergic system sometimes. Therefore, to treat them, to restore the neurotransmitter and neurophysiological balance used antagonists of dopamine receptors (for example, Generic Artane), tools that increase GABAergic transmission (benzodiazepines, Buckley, hair dryer, sodium valproate).
